
TC-N 1752
CAS No. 1211866-85-1
TC-N 1752 ( —— )
产品货号. M27722 CAS No. 1211866-85-1
TC-N 1752 是一种有效和具有口服活性的 Nav1.7 抑制剂,抑制 hNav1.7,hNav1.3,hNav1.4,hNaV1.5 和 rNav1.8 的 IC50 值分别为 0.17 μM,0.3 μM,0.4 μM,1.1 μM 和 2.2 μM。TC-N 1752 还抑制河豚毒素敏感的钠通道。TC-N 1752 在福尔马林疼痛模型中显示出镇痛效果。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥988 | 有现货 |
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10MG | ¥1604 | 有现货 |
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25MG | ¥3686 | 有现货 |
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50MG | ¥5443 | 有现货 |
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100MG | ¥7744 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称TC-N 1752
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述TC-N 1752 是一种有效和具有口服活性的 Nav1.7 抑制剂,抑制 hNav1.7,hNav1.3,hNav1.4,hNaV1.5 和 rNav1.8 的 IC50 值分别为 0.17 μM,0.3 μM,0.4 μM,1.1 μM 和 2.2 μM。TC-N 1752 还抑制河豚毒素敏感的钠通道。TC-N 1752 在福尔马林疼痛模型中显示出镇痛效果。
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产品描述human NaV1.7 channels blocker.(In Vitro):TC-N 1752 exhibits IC50s of 0.2, 0.1, 1.6, 0.5 and 1.4 μM for hNav1.7, hNav1.8, hNav1.9, rNav1.9, and mNav1.9. TC-N 1752 state-dependently inhibits Nav1.7 channel on channels that are 20% inactivated(IC50 = 170 nM) and on fully noninactivated channels(IC50 = 3.6 μM).(In Vivo):TC-N 1752 (5 mg/ml; i.v.) attenuates Freund's adjuvant-induced sensitization of C fiber nociceptors. TC-N 1752 (3-30 mg/kg; orally) exhibits analgesic effects in a dose-dependent manner in a formalin model and reduces thermal hyperalgesia produced by inflammation.
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体外实验TC-N 1752 (compound 52) state-dependently inhibits Nav1.7, with IC50 of 170 nM on channels that are 20% inactivated and IC50 of 3.6 μM on fully noninactivated channels.TC-N 1752 inhibits hNav1.7, hNav1.8, hNav1.9, rNav1.9, and mNav1.9 with IC50s of 0.2, 0.1, 1.6, 0.5 and 1.4 μM, respectively.
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体内实验TC-N 1752 (compound 52) (3-30 mg/kg; p.o.) dose-dependently shows analgesic effect in the Formalin model.TC-N 1752 (3-30 mg/kg; p.o.) decreases thermal hyperalgesia produced by inflammation.TC-N 1752 (5 mg/mL; 500 μL; i.v.) attenuates complete Freund’s adjuvant (CFA)-induced sensitization of C-fiber nociceptors. Animal Model:Rats were injected intraplantar with Formalin Dosage:3, 10, 20, 30 mg/kg Administration: Administered p.o. 120 min prior to Formalin Result:Showed analgesic efficacy starting at the dose of 3 mg/kg, with full efficacy at 20 mg/kg dose.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1211866-85-1
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分子量516.525
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分子式C25H27F3N6O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (242.00 mM)
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SMILESC\C(O)=N\c1cccc(\N=c2/ncnc([nH]2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Wang RY, et al. From kinetic-structure analysis to engineering crystalline fiber networks in soft materials. Phys Chem Chem Phys. 2013 Mar 7;15(9):3313-9.
产品手册




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