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TC-N 1752

CAS No. 1211866-85-1

TC-N 1752 ( —— )

产品货号. M27722 CAS No. 1211866-85-1

human NaV1.7 channels blocker.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥988 有现货
10MG ¥1604 有现货
25MG ¥3686 有现货
50MG ¥5443 有现货
100MG ¥7744 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    TC-N 1752
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    human NaV1.7 channels blocker.
  • 产品描述
    human NaV1.7 channels blocker.(In Vitro):TC-N 1752 exhibits IC50s of 0.2, 0.1, 1.6, 0.5 and 1.4 μM for hNav1.7, hNav1.8, hNav1.9, rNav1.9, and mNav1.9. TC-N 1752 state-dependently inhibits Nav1.7 channel on channels that are 20% inactivated(IC50 = 170 nM) and on fully noninactivated channels(IC50 = 3.6 μM).(In Vivo):TC-N 1752 (5 mg/ml; i.v.) attenuates Freund's adjuvant-induced sensitization of C fiber nociceptors. TC-N 1752 (3-30 mg/kg; orally) exhibits analgesic effects in a dose-dependent manner in a formalin model and reduces thermal hyperalgesia produced by inflammation.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1211866-85-1
  • 分子量
    516.5
  • 分子式
    C25H27F3N6O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    C\C(O)=N\c1cccc(\N=c2/ncnc([nH]2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Wang RY, et al. From kinetic-structure analysis to engineering crystalline fiber networks in soft materials. Phys Chem Chem Phys. 2013 Mar 7;15(9):3313-9.
产品手册
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